Efficacy of crizotinib, ceritinib, and alectinib in ALK-positive non-small cell lung cancer treatment: a meta-analysis of clinical trials

This study aimed to evaluate the efficacy of anaplastic lymphoma kinase (ALK)-inhibitors in the treatment of ALK-positive non-small cell lung cancer (NSCLC) by using a meta-analysis of clinical trials. We searched PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov by using keywords related to the topic in August 2018. The pooled effect sizes were calculated based on a random-effects model. We also performed subgroup meta-analysis by types of ALK inhibitors (crizotinib, ceritinib, and alectinib). A total of 20 clinical trials with 10 single-arm trials and 10 double-arm trials were included in the final meta-analysis. The median overall survival (OS), progression-free survival (PFS), overall response rate (ORR), disease control rate (DCR), 1 year survival rate, and 2 year survival rate were 19.14 months, 8.47 months, 62%, 78%, 74%, and 62%, respectively. ALK inhibitors showed a significantly superior efficacy compared with chemotherapy (hazard ratio (HR) for OS, 0.83; HR for PFS, 0.43; rate difference (RD) for ORR, 0.23; and RD for DCR, 0.10). The current meta-analysis of clinical trials showed the significant efficacy of ALK inhibitors in the treatment of ALK-positive NSCLC. Further head-to-head trials are needed to compare their efficacy with other types of NSCLC treatment regimens. PROSPERO registration: CRD42018085987

Non-minimal Einstein-Yang-Mills-Higgs theory: Associated, color and color-acoustic metrics for the Wu-Yang monopole model

We discuss a non-minimal Einstein-Yang-Mills-Higgs model with uniaxial anisotropy in the group space associated with the Higgs field. We apply this theory to the problem of propagation of color and color-acoustic waves in the gravitational background related to the non-minimal regular Wu-Yang monopole.Comment: 14 pages, no figure

Age restriction warning label efficacy and high school student consumption of highly-caffeinated products.

Age restriction warning labels (ARLs) are placed on highly-caffeinated food and drinks, such as Red Bull, to deter consumption by minors who are especially vulnerable to the risks of excessive caffeine consumption. Previous studies have shown that ARLs on media like TV programs and video games fail to discourage minors. However, it is unclear how ARLs on food and drink packages affect minors\u27 purchasing behavior. High school students aged 14 to 17 years (n = 150,

An enhancement to the Bees Algorithm with slope angle computation and Hill Climbing Algorithm and its applications on scheduling and continuous-type optimisation problem

This paper focuses on improvements to the Bees Algorithm (BA) with slope angle computation and Hill Climbing Algorithm (SACHCA) during the local search process. First, the SAC was employed to determine the inclination of the current sites. Second, according to the slope angle, the HCA was utilised to guide the algorithm to converge to the local optima. This enabled the global optimum of the given problem to be found faster and more precisely by focusing on finding the available local optima first before turning the attention on the global optimum. The proposed enhancements to the BA have been tested on continuous-type benchmark functions and compared with other optimisation techniques. The results show that the proposed algorithm performed better than other algorithms on most of the benchmark functions. The enhanced BA performs better than the basic BA, in particular on higher dimensional and complex optimisation problems. Finally, the proposed algorithm has been used to solve the single machine scheduling problem and the results show that the proposed SAC and HCA-BA outperformed the basic BA in almost all the considered instances, in particular when the complexity of the problem increases

``Superfast'' Reaction in Turbulent Flow with Potential Disorder

We explore the regime of ``superfast'' reactivity that has been predicted to occur in turbulent flow in the presence of potential disorder. Computer simulation studies confirm qualitative features of the previous renormalization group predictions, which were based on a static model of turbulence. New renormalization group calculations for a more realistic, dynamic model of turbulence show that the superfast regime persists. This regime, with concentration decay exponents greater than that for a well-mixed reaction, appears to be a general result of the interplay among non-linear reaction kinetics, turbulent transport, and local trapping by potential disorder.Comment: 14 pages. 4 figures. Uses IOP styles. To appear in J. Phys. A: Math. Ge